Although a similar prevalence of anti-HHV-6A/B antibodies in the SSc group and healthy controls (76.8 vs. 75%), the prevalence and titer of anti-U94 antibodies were significantly higher in the SSc population (100%, median titer 1:400) compared to controls (46.7%, median titer 1:166) (p < 0.004), confirming previous similar observations in multiple sclerosis patients [45]. The gene discussed is SNORD94; the disease is systemic sclerosis.