The results showed both a different prevalence and titer of the anti-U94 antibodies in the SSc group compared to the healthy controls (p < 0.004), as the presence of anti-U94 antibodies was detected in 26/26 (100%) of the SSc patients and in 14/30 (46.7%) of the healthy subjects; in addition, their titer was significantly higher in the SSc group (median titer 1:403, range 1:100–800), whereas control group displayed a mean titer corresponding to 1:166 (range 1:50–400), confirming previous results [45]. This evidence concerns the gene SNORD94 and systemic sclerosis.