Interesting in this respect is the implication in microcephaly, in addition to the OMIM-recognized genes, of the gene encoding RAN-binding protein 1 (RANBP1) [64], a regulator of the RAN nucleotide guanosine triphosphate (GTP) hydrolase (GTPase), that controls centrosome cohesion [65,66]. The gene discussed is RANBP1; the disease is microcephaly.