In multiple independent human LAM lung patient-derived cell lines, under the cell culture conditions used, rapamycin (10 nM) inhibited the phosphorylation of S6 (Ser235/236) but not the phosphorylation of 4E-BP1 (Thr37/46) (Figure 2A). Here, EIF4EBP1 is linked to lymphangioleiomyomatosis.