TSC2 and lymphangioleiomyomatosis: In a TSC2-null LAM patient-derived angiomyolipoma cell line 621–102, pS6 and peIF4E were co- expressed mainly in the cytoplasm (Figure 3A) and the immunofluorescent signals could be inhibited by rapamycin (10 nM) plus eFT508 (1 μM) (Figure 3B).