Tularemia vaccine induced higher guanylate binding protein (GBP) responses at Day 2, with upregulation of genes encoding for GBP1P1, GBP5, GBP1, and GBP4 compared to the other vaccines at Day 3 (Figure 4A, blue bracket, Supplemental Tables S85, S87, and S89). Here, GBP5 is linked to tularemia.