Additionally, DCBLD1 expression is upregulated in the HPV negative non-smoker patients subgroup, in comparison to HPV positive (p < 0.001) and HPV negative smoker patients (p = 0.001) (Figure 2C), thus strengthening the hypothesis that it is the complete absence of HNSCC risk factor which is associated with the rs6942067 GG genotype. This evidence concerns the gene DCBLD1 and head and neck squamous cell carcinoma.