Indeed, Brancia and coworkers demonstrated that TLQP peptides expression decreases both in vitro, in stressed NSC-34 cells and untreated fibroblast cultures from ALS patients, as well as in vivo, in motor neurons of Superoxide Dismutase-1 (SOD1) mice at the earliest, pre-symptomatic stage of the pathology, before the onset of significant muscle weakness took place. Here, SOD1 is linked to amyotrophic lateral sclerosis.