CD8A and neoplasm: The immuno-suppressive function of TAMs is also mediated by the secretion of TGFβ, as well as IL-10, that suppress CD8+ T cell functions by direct transcriptional repression of genes encoding functional mediators, such as perforins, granzymes, and cytotoxins; but also indirectly by stimulating the amplification of Treg cells or by suppressing DC anti-tumor functions [20,34,35].