TP53 and juvenile Huntington disease: Protein Analysis Through Evolutionary Relationships revealed that cholecystokinin receptor pathway, platelet-derived growth factor signaling, oxidative stress response, B-cell activation, interleukin signaling, Huntington disease, Wnt pathway, heterotrimeric G-protein signaling pathway-rod outer segment, heterotrimeric G-protein signaling pathway-Gi alpha subunit, Gi alpha-mediated pathway, p53 pathway positive and negative feedback loops 2, T-cell activation, and transforming growth factor-β signaling pathway were involved (Figure 2B).