ABCG2 and central nervous system cancer: Recently, it was reported that Fasudil (HA-1077), an inhibitor of Rho-associated protein kinases (ROCKs) used in China and Japan for the treatment of cerebral vasospam, increases the temozolomide (TMZ) sensitivity of TMZ-resistant gliomas in vitro and in xenografted mouse and rat by suppressing the expression of BCRP through the ROCK2/moesin/β-catenin pathway [382].