Zhao et al. reported that resveratrol could significantly improve the impaired memory formation and synaptic plasticity in AD via downregulating the miR-124 level, which is accompanied with an increase of CREB and subsequently promoted BDNF synthesis [45], a key molecule in the neurobiological mechanisms relates to dendritic spine size and cognitive decline and also possesses neuroprotective properties against Aβ-induced neurotoxicity in cultured neurons and AD mouse models [105]. The gene discussed is CREB1; the disease is Alzheimer disease.