MAP3K3 and Parkinson disease: Yao et al. identified a unique protective role of the exogenous delivery of miR-124, which could effectively attenuate the activation of microglial in the substantia nigra pars compacta of MPTP-induced PD model via targeting and suppressing mitogen-activated protein kinase kinase kinase 3 (MEKK3)/NF-kB signaling pathway [52].