AKT1 and ischemic stroke: Wang et al. observed that miR-124 exerted an anti-apoptosis effect in ischemic stroke via activating phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB/AKT) signaling pathway, a well-established signaling pathway positively affected expression of B-cell lymphoma-2 (Bcl-2), further alleviated cell apoptosis in ischemic stroke [40].