TP53 and ischemic stroke: MiR-124 could also downregulate the expression of inhibitory member of the apoptosis-stimulating proteins of p53 family (iASPP) in the early stage of ischemic stroke, suppressing this endogenous pro-survival pathway and promoting neuronal apoptosis after ischemic stroke, while the inhibition of miR-124 upregulated the level of iASPP and effectively decreased infarct volume [36].