However, transfection of miR-124-3p mimics exerted a protective role in AD by attenuating the abnormal hyperphosphorylation of tau protein and tau-induced cell apoptosis through directly targeting and repressing Caveolin-1 expression, which promoted the activation of PI3K/AKT and phosphorylated GSK-3β, subsequently inhibited the activity of GSK-3β [35]. This evidence concerns the gene GSK3B and Alzheimer disease.