BCL2 and ischemic stroke: In addition, miR-124 suppresses apoptosis in ischemic stroke via directly targeting and upregulating Bcl2, Bcl-xl [42], Usp14 [38], JAK/STAT3 [77], and PI3K/AKT/Nrf2 signaling pathways [41], while other researchers reported that miR-124 promotes neuronal apoptosis through inhibiting iASPP [36] and Ku70 [43] in ischemic stroke (Figure 1).