Moreover, Dong et al. identified miR-124-3p as a neuronal protector by targeting and suppressing annexin 5 (ANAX5)/extracellular regulated protein kinases (ERK) signaling pathway, subsequently ameliorated 6-OHDA-induced neurotoxicity via alleviating ROS accumulation-mediated Caspase-3 activation, and apoptosis in PD [50]. The gene discussed is CASP3; the disease is Parkinson disease.