More importantly, the downregulated miR-124 in MPTP-treated neurons could induce neurons apoptosis and autophagy-associated protein expression via activating p-AMPK, and then led to the inhibition of p-mTOR signaling, while the upregulation of miR-124 acted as a protector of dopamine neurons by suppressing cell apoptosis and autophagy through AMPK/mTOR signaling pathway in PD [48]. The gene discussed is MTOR; the disease is Parkinson disease.