F3 and endothelial dysfunction: The protein expression levels of p53, p16 (a down-stream modulator of cell cycle arrest), tissue factor (TF, the cellular initiator of the coagulation cascade), MMP-9 (a matrix metalloproteinase involved in extracellular matrix remodeling), and eNOS (the pivotal endothelial NO synthase that participates in redox-induced senescence and endothelial dysfunction when down-regulated) were investigated.