TRPC6 and renal fibrosis: In the Wu et al. study, the authors also examined the effects of soluble klotho in the UUO model on the basis of the following observations: (1) the investigators had previously demonstrated that soluble klotho inhibits TRPC6 exocytosis and TRPC6 currents in the heart [167], and (2) treatment with soluble klotho inhibits renal fibrosis in obstructed kidneys [168].