TRPC6 and Hyperglycemia: In support of a role for TRPC6 in diabetic nephropathy, glomerular expression of TRPC6 is upregulated in kidneys from rodent models of diabetes [61,64,65,66,67,69], and knockdown of TRPC6 in cultured podocytes both inhibits hyperglycemia-induced apoptosis [90,131] and preserves podocin expression [69].