Since these initial observations, enhanced expression of TRPC6 has been demonstrated in other kidney diseases including rodent models of diabetic nephropathy [61,64,65,66,67,68,69], nephrotoxic serum nephritis [70,71], rodent models of FSGS [61,64,72,73,74], and ureteral obstruction [75,76]. This evidence concerns the gene TRPC6 and focal segmental glomerulosclerosis.