NOS3 and atherosclerosis: Specifically, Lee et al. [151], utilized a combination of swimming training and dietary supplementation over an 8-week period, reporting that oxidative stress was reduced by reducing 4-hydroxynonenal (4-HNE), aorta vasodilatation was enhanced through increased NO and eNOS expression in aorta, while CRP and pro-inflammation proteins were reduced, in aged rats with diet-induced atherosclerosis.