The reduced mRNA levels of the Wnt target genes C-myc, Bcl-2, and Axin2 in the WD group could be due to the lower expression of the transcription factor of the Wnt pathway Tcf4. Axin2 and Gsk-3β, that promote degradation of β-catenin [34], were higher expressed in the AIN group, suggesting that the activity of the canonical Wnt signaling was still under control and served the physiological process of tissue regeneration. This evidence concerns the gene GSK3B and Wilson disease.