TCF4 and Wilson disease: The reduced mRNA levels of the Wnt target genes C-myc, Bcl-2, and Axin2 in the WD group could be due to the lower expression of the transcription factor of the Wnt pathway Tcf4. Axin2 and Gsk-3β, that promote degradation of β-catenin [34], were higher expressed in the AIN group, suggesting that the activity of the canonical Wnt signaling was still under control and served the physiological process of tissue regeneration.