AR and posterior cortical atrophy: Loss of the miR-15A-miR-16-1 cluster on chromosome 13, AR mutation and amplification, overexpression of multiple oncogenes such as CXCR4, EZH2, cMYB, activation of several oncogenic pathways and various mutations including FOXA1, BRACA1/2, and ATM are also reported to correlate with the PCa progression from early stage to metastatic disease.