This effect highlights the importance of Beclin 1 on a CML mouse model, although this experiment cannot ascertain whether the effect that is seen is due to changes associated with autophagy, Beclin 1 autophagy-independent functions or to the BCR-ABL-phosphorylated Beclin 1. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.