Decreased Beclin 1 proteins have been reported in breast cancers compared to normal tissue [2,31], as well as in other cancer entities, such as ovarian carcinomas [32,33], colon cancer [34,35], non-small cell lung cancer [36,37], cholangiocarcinoma [38], gastric cancer [39,40], and renal cell carcinoma [41]. Here, BECN1 is linked to hereditary clear cell renal cell carcinoma.