TSC2 and neoplasm: Becn1+/− mice have been used to study several tumor entities: Subcutaneous melanoma xenografts showed increased hypoxia-induced angiogenesis in Becn1+/− mice as compared to the Becn1+/+ mice [93]; T-cell lymphoma development in Atm−/− mice is delayed when crossed with Becn1+/− mice, although the effects in Eu-myc transgenic mice, a mouse model of Burkitt lymphoma [94], seems to accelerate the disease onset, highlighting the importance of examining each individual tumor type and stage; Becn1+/− mice also reduced Tsc2+/− tumorigenesis in the kidney [95].