Finally, C-terminal heparin-binding Fn-fs induce MMP-3 and MMP-13 production in bovine cartilage [196], MMP-1, MMP-2, MMP-9, and MMP-13 in human cartilage [197], as well as MMP-1, MMP-3, and MMP-13 in RA-SF [198]. The gene discussed is MMP13; the disease is rheumatoid arthritis.