Honokiol affects the constitutive activation of NFκB and expression of NFκB-regulated gene products involved in apoptosis (survivin, Bcl-2, Bcl-xL, IAP1, IAP2, cFLIP and TRAF1), inflammation (cyclooxygenase-2, COX-2), proliferation (cyclin D1 and c-myc), invasion (ICAM-1 and MMP-9), and angiogenesis (VEGF), thereby enhancing apoptosis and suppressing cancer progression [58,174]. Here, PTGS2 is linked to cancer.