When tested on Lewis lung tumour (LLT) cells, the polymeric micelles show powerful cytotoxicity, effective suppression on vasculogenic mimicry (VM) channels and tumour metastasis, as well as the activation of apoptotic enzymes caspase-3 and caspase-9, and down-regulation of FAK, PI3K, MMP-2, and MMP-9 [236]. This evidence concerns the gene MMP9 and neoplasm.