AKT1 and breast cancer: In MDA-MB-231 human breast cancer cells, honokiol downregulated the expression and phosphorylation of c-Src, epidermal growth factor receptor (EGFR), and Akt, and consequently led to the inactivation of mTOR and its downstream signal molecules including 4E-binding protein (4E-BP) and p70 S6 kinase [43].