Several studies support the inhibitory activity of honokiol against NFκB in different types of cancer cells, including breast cancer [42,117,175], head and neck squamous cell carcinoma (HNSCC) [176], colon cancer cells [177], non-small cell lung cancer (NSCLC) cells [44], pancreatic cancer cells [13], human leukemic cell [104], embryonic kidney cells, T-cell leukemia, multiple myeloma, lung adenocarcinoma, and squamous cell carcinoma [174]. Here, NFKB1 is linked to head and neck squamous cell carcinoma.