Honokiol has been shown to target STAT3 to reduce its expression and phosphorylation in many cancer cells such as human glioblastoma [47,63,100], lung cancer [47,181], oral squamous cell carcinoma (OSCC) [95], breast cancer [41,144], human epidermoid carcinoma [31], colorectal cancers [182], gastric cancer [87], and esophageal adenocarcinoma [119]. Here, STAT3 is linked to esophageal adenocarcinoma.