Considering the fact that MYC expression is up-regulated in a large proportion of CRC [47,48] and that data indicating that MYC controls the expression of many genes in CRC cells including several key integrin subunits [40], which comprise ITGB4 [25], MYC represents a potential regulator of ITGA6 transcription. The gene discussed is MYC; the disease is colorectal carcinoma.