Incidentally, based on the use of genetically modified mouse Itga6 mutant models, De Archangelis et al. concluded that the α6β4 integrin could be classified as a tumour suppressor in the colon based on their observations that depletion of the α6 subunit in intestinal epithelial cells leads to a chronic inflammation that drives the subsequent development of tumors [53], albeit numerous indications that it may drive CRC progression instead, a phenomenon that may be the result of the opposite effect of α6A and B subunit variants on cell functions such as proliferation [54], as summarized above. This evidence concerns the gene ITGA6 and colorectal carcinoma.