Urinary peptidomics CKD273 subclassifiers outperformed CKD classifier and urinary albumin for predicting rapid loss of eGFR in individuals with baseline eGFR > 60 mL/min/1.73 m2, and even predicted a rapid CKD progression in individuals with eGFR > 60 mL/min/1.73 m2 and albuminuria < 30 mg/day. This evidence concerns the gene ALB and chronic kidney disease.