Since the levels of cyclin D3 and CDK4 are increased in the neurogenic muscle atrophy [63], it is possible that the phosphorylation of CUGBP1 at Ser-302 might affect splicing activity of CUGBP1 towards RyR1 in neurogenic atrophy as well as in DM1 muscle pathology. This evidence concerns the gene CELF1 and myotonic dystrophy type 1.