In addition, Ca2+-dependent tyrosine kinase Pyk2 might phosphorylate GSK3β at Tyr-216 in DM1, because Pyk2 activates GSK3β in vitro and in neuronal cells during lysophosphatidic acid (LPA)-induced neurite retraction [55,56]. Here, GSK3B is linked to myotonic dystrophy type 1.