Prevention of DM1 muscle pathology in adult HSALR mice, shortly treated with BIO at a young age, was accompanied by the correction of GSK3β and cyclin D3, normalization of CUGBP1 levels and its activity, determined by the interaction of CUGBP1 with active eIF2α [49]. Here, CELF1 is linked to myotonic dystrophy type 1.