As a result, the MFI of galectin 3 C-terminal-S (Gal3C-S) lectin, which recognized mucin-type O-glycan, -reactive OPN (Gal3C-S-OPN)/uFL-OPN level was significantly higher in primary stone forming urolithiasis patients [median, 52.3 MFI/ng/mL, interquartile range (IQR) 4.72–111.60] and recurrent stone forming urolithiasis patients (median, 72.0 MFI/ng/mL, IQR, 21.49–144.20) than that of HVs (median, 0.0074 MFI/ng/mL, IQR, 0.0030–0.0199]) (p < 0.0001, respectively) (Table 1, Figure 2). The gene discussed is SPP1; the disease is urolithiasis.