Although the role of CCDC6 in NSCLC should be further investigated, the results discussed here clearly suggest that the evaluation of CCDC6 protein by IHC, besides considering the levels of protein expression, should also consider the evaluation of protein distribution in the cancer cells (nucleus > cytosol) which might be consequential of CCDC6 molecular alterations. This evidence concerns the gene CCDC6 and non-small cell lung carcinoma.