CCDC6 and lung carcinoma: Similarly, the IC50 values of the NCI-H1975 lung cancer cells expressing the truncated isoform of CCDC61–101 indicated cis-platinum resistance and Olaparib sensitivity compared to control cells (Figure 5A–C), according to the dominant negative activity exerted by the CCDC61–101 truncated isoform with respect to the CCDC6 wild type function in HR DNA repair process, as reported in the previous paragraph.