CCDC6 and neoplasm: Recently, almost 135 molecular alterations in CCDC6 gene have been identified so far in different tumor types, consisting of missense mutations (13.79 %), nonsense mutations (2.30 %) and either insertion or deletion (2.3%), all distributed along the entire sequence of the gene with no evident hot spots of mutation (https://cancer.sanger.ac.uk/cosmic) [35].