In line with these findings, it has been shown in e.g., ovarian and colorectal cancer cells that a lack of SDHB leads to HIF-1-dependent metabolic alterations towards a more glycolytic phenotype [36,46] which is associated with induction of Epithelial-Mesenchymal-Transition (EMT) and elevated proliferation [37,38,47]. The gene discussed is SDHB; the disease is colorectal cancer.