SDHB and neoplasm: With regard to the tumor suppressor function of SDHB its upregulation in PDECs due to co-culture with M1-macrophages might, thus, be considered as a counterregulatory, tumor preventive mechanism in order to sensitize cells for apoptotic stimuli and, thereby, impede excessive cell proliferation under pro-inflammatory conditions that favor malignant transformation [35,53,54,55].