SDHB and cancer: In fact, metabolic reprogramming as well as SDH inhibition have also been shown to essentially contribute to EMT and with this to the acquisition of an invasive and cancer stem cell phenotype [47,61] Giving the fact that macrophages represent a predominant cell population in the stroma of CP and PDAC and are known to promote EMT and cell invasion of PDECs [13], it can be speculated that they might also impact these processes via paracrine modulation of SDHB expression.