Other genes with altered expression levels were the anti-apoptotic BCL2 (upregulated; p < 0.05), the epithelial-to-mesenchymal transition marker TWIST1 (downregulated; p < 0.01), the stem cell marker TACSTD2 (downregulated; p < 0.05), and AGR2, an androgen-regulated gene associated with metastasis in PC [16,17,18] (downregulated; p < 0.01) (Figure 1D). The gene discussed is TWIST1; the disease is pachyonychia congenita.