An example of this type of protein is the PD1-Fc-OX40L molecule, which, on testing, retained its high affinity binding for both PD-L1/L2 and OX40, caused T-cell activation and also demonstrated an improved anti-tumor immune response compared with single antibody treatment or the combination of the two separate PD-1 and OX40 antibodies [83]. This evidence concerns the gene TNFRSF4 and neoplasm.