The manifestation of NASH in the diet-induced in vivo model was mediated by the oxidative stress and subsequent activation of Na/K-ATPase signaling, which was confirmed by the increase in protein carbonyls along with western blot analysis that showed activation of the Na/K-ATPase signaling downstream mediators Src and ERK 1/2 [9]. This evidence concerns the gene SRC and metabolic dysfunction-associated steatohepatitis.