ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Considering the effectiveness of systemic administration of pNaKtide in ameliorating the obesity phenotype, recent studies employed a lentiviral construct with NaKtide, a derivative of pNaKtide, which was driven by an adiponectin promoter to achieve its expression specifically in adipocytes and inhibit adipocyte Na/K-ATPase signaling [48].