CXCR4 and neoplasm: In addition the elevated local 22rv1 tumor growth associated to the ability to sustain angiogenesis and mediate inflammation through the secretion of CXCR4 ligands, SDF1a and MCP1, makes 22rv1 cells a good model for studying the capacities of CXCR4 inhibitors in a non-metastatic primary tumor model as may be the subcutaneous xenograft model.