Other chemokines directly targeted by the SCP3 (CCL20, CCL25, CCL28, CXCL12b, CXCL13, CXCL14, XCL1 and CX3CL1) have been shown to contribute to the pathogenesis of RA, including CXCL13, which may recruit B-cells into inflamed joints, or CCL28 that participates in angiogenesis [45]. This evidence concerns the gene CXCL13 and rheumatoid arthritis.