CX3CL1 and rheumatoid arthritis: Other chemokines directly targeted by the SCP3 (CCL20, CCL25, CCL28, CXCL12b, CXCL13, CXCL14, XCL1 and CX3CL1) have been shown to contribute to the pathogenesis of RA, including CXCL13, which may recruit B-cells into inflamed joints, or CCL28 that participates in angiogenesis [45].