To reveal the function of CREPT in melanoma, BLM cells were stably transfected with CREPT coding sequence plasmid and empty vector (shown as “CREPT” and “Control”, respectively, in Figure 2, Figure 3, Figure 4, Figure 5, Figure 6 and Figure 7) for enhanced expression, and with plasmids inserted with short hairpin RNA (shRNA) against CREPT and scrambled shRNA (shown as “shCREPT” and “shNC”, respectively, in Figure 2, Figure 3, Figure 4, Figure 5, Figure 6 and Figure 7) for depleted expression (Figure S1). This evidence concerns the gene RPRD1B and melanoma.