CD4 and uveitis: Animal models of autoimmune uveitis fall into two distinct groups (Caspi, 2010): firstly, those where uveitis is induced by injection of a retinal protein with an adjuvant resulting in a CD4+ T lymphocyte-mediated intraocular inflammation; and secondly, those in which uveitis arises spontaneously such as the R161H model, where mice are transgenic for a T cell receptor specific for the retinal antigen interphotoreceptor retinoid binding protein (Horai et al., 2015).