In chinchillas with experimental OM, NTHi density in the nasal passages, which confers OM development, could be reduced via intranasal application of a recombinant chinchilla beta-defensin 1 (cBD1) as well as the human ortholog HBD3, demonstrating the capacity of these innate molecules to clear bacterial otopathogen [14]. This evidence concerns the gene DEFB1 and ocular melanoma.