DEFB1 and coinfection: Reducing the availability of chinchilla beta-defensin 1 (equivalent to human beta-defensin 3) through RSV co-infection or with a blocking antibody resulted in increased NTHi loads from nasopharyngeal lavage fluids while increasing the availability of chinchilla beta-defensin 1, via delivery of a recombinant form, was associated with reduced NTHi loads [14].