BRCA1 and Fanconi anemia: Like BRCA1 (FANCS) [25] and BRCA2 (FANCD1) [26], monoallelic mutations in PALB2 confer familial susceptibility to breast, ovarian and pancreatic cancer [4, 7], while biallelic PALB2 lesions cause Fanconi anemia (FA) subtype N (FANCN) [27].