BRCA1 and neoplasm: Like Brca1flox/+; KPC or Brca2flox/+; KPC mice, tumor latency of Palb2flox/+; KPC animals was similar to KPC animals and the tumors maintained the intact wild type allele as well as functional HR (Fig 5B), which is consistent with previous reports showing that deletion one allele of Palb2, Brca1 or Brca2 in mice did not affect tumor frequency or genome stability [16, 66].