Since both germline and somatic mutations in PALB2 and BRCA1/2 genes were found in a significant proportion of pancreatic cancer cases [8], to understand those tumors better, it is also important to study whether tumors derived from defected function of PALB2, BRCA1 and BRCA2 are caused through a same mechanistic pathway by comparing similarities and differences between PALB2 and BRCA1/2 tumors. This evidence concerns the gene BRCA1 and familial pancreatic carcinoma.