Therefore, we generated the Palb2-KPC (Palb2flox/flox; KrasG12D; p53R270H/+;Pdx1-Cre), Brca1-KPC (Brca1flox/flox; KrasG12D; p53R270H/+;Pdx1-Cre), Brca2-KPC (Brca2flox/flox; KrasG12D; p53R270H/+; Pdx1-Cre), or KPC (KrasG12D; p53R270H/+; Pdx1-Cre) animals, and monitored tumor development. This evidence concerns the gene PDX1 and neoplasm.