To test this hypothesis, we generated Palb2-, Brca1- and Brca2- deficient pancreatic tumor mouse models and have shown that loss of Palb2 cooperates with mutant p53R270H and KrasG12D in the development of PDACs, similarly to the Brca1- and Brca2-KPC mouse pancreatic tumor models, but Palb2-, Brca1- and Brca2-KPC tumors were not identical. Here, PALB2 is linked to pancreatic neoplasm.