Previous studies showed strong associations between the lipid metabolism associated genes including the hepatic lipase (LIPC) locus rs10468017, lipoprotein lipase (LPL) locus rs10468017 and cholesterol ester transfer protein (CETP) based on the drusen that is a mound between the RPE cell and its basement membrane and mainly consist of liquids and the development of age-related macular disease (AMD) [9–11]. The gene discussed is CETP; the disease is age-related macular degeneration.