The updated Position Statement [3] by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) endorsed the addition of one of the following glucose-lowering medications as a third-line option when optimal glycemic control is not achieved after 3 months of dual therapy: thiazolidinedione (TZD), dipeptidyl peptidase‐4 inhibitors (DPP4i), sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors, glucagon‐like peptide‐1 receptor agonists (GLP1-RAs), or basal insulin regimen. The gene discussed is SLC5A2; the disease is diabetes mellitus.