RASSF1 and hepatocellular carcinoma: It has the capability to trigger autophagy defects to facilitate oxidative stress and genome instability, thus accelerating tumorigenesis.67 We revealed that RASSF1A methylation discriminated HCC patients from control individuals with a SEN of 0.644 and a SPE of 0.875, contributing to an improvement of AUC from 0.787 to 0.841.