The VEGFR2 rs11941492 TT genotype (TT vs CT + CC) may decrease the risk of RA among female patients (OR = 0.54, 95% CI = 0.34–0.85, P = .008), CRP-positive patients (OR = 0.55, 95% CI = 0.34–0.89, P = .014), ACPA-negative patients (OR = 0.60, 95% CI = 0.36–0.99, P = .047), RF-positive patients (OR = 0.60, 95% CI = 0.39–0.90, P = .015), patients with a DAS28 of ≥3.20 (OR = 0.66, 95% CI = 0.44–0.99, P = .046), and those with an ESR of <25 (OR = 0.54, 95% CI = 0.31–0.92, P = .022) (Table 3). The gene discussed is KDR; the disease is rheumatoid arthritis.