In stratification analysis, we also identified a decreased risk of RA associated with the VEGFR2 rs11941492 TT genotype (TT vs CC, and TT vs CT + CC) among female, CRP-positive, ACPA-negative, and RF-positive patients, and in patients with a DAS28 of ≥3.20 or an ESR of <25. Here, CRP is linked to rheumatoid arthritis.