In stratification analysis, we also found a decreased risk of RA was associated with the VEGFR2 rs11941492 TT genotype (TT vs CC) among female patients, older patients (Yr ≥55), CRP-positive patients, ACPA-negative patients, RF-positive patients, functional class III + IV patients, patients with a DAS28 of ≥3.20, and those with an ESR of <25. The gene discussed is PRTN3; the disease is rheumatoid arthritis.