Age, estrogen receptor status, progesterone receptor status, Ki-67 count, menopause status[23] are important to breast cancer patients for prognosis and treatment, so we created model 2 with age, estrogen receptor status, progesterone receptor status, Ki-67 count, menopause status, being based on the clinicopathologic variables that were important for the overall survival rate and disease-free survival rate, besides the variables in model 1. The gene discussed is ESR1; the disease is breast cancer.