It is not surprising that CT-reported N1/N2 classification, poor differentiation, and elevated CEA and CA19-9 levels increased the risk of LI, which were basic route in the diagnostic criteria and treatment of CRC guided by the NCCN.[29] Furthermore, the nomogram consisted of readily available factors that are subject to little interobserver variability. Here, CEACAM5 is linked to colorectal carcinoma.