INS and pulmonary fibrosis: Impaired PAEC function may contribute to the increased rate of BPD.[39] Furthermore, a related paper on Metformin reversing established lung fibrosis in a bleomycin model was published in 2008; it implicated INS in alleviating the later pathological change of BPD.[40] Usually, the limitation for text mining–based strategies is that there is no chance to discover new genes.[19] Interestingly, in this study we found INS as a novel gene related to BPD by accident.