Furthermore, CAMK2N1 caused down‐regulation of MEK/ERK activity and up‐regulation of p27 protein, which regulates the cell cycle progression of colon cancer cells,13, 14 and induced apoptosis regulatory kinases including Bax/Bcl2, caspase4, caspase7.15 These studies suggested how CAMK2N1 inhibited tumourigenesis via regulating cell cycle and improving cell apoptosis. This evidence concerns the gene CDKN1B and malignant colon neoplasm.