Sorting nexin 16 (SNX16), which is significantly upregulated in colorectal cancer, could interact with and inhibit proteasome‐dependent ubiquitination of eukaryotic translation elongation factor 1 A2 (eEF1A2), thereby activating c‐myc signaling, Our study unveiled that SNX16/eEF1A2/c‐Myc signaling axis could promote colorectal tumorigenesis and SNX16 might potentially serve as a novel biomarker for the diagnosis and intervention of colorectal cancer. Here, EEF1A2 is linked to colorectal cancer.