Thus, PD biomarkers of sensitivity to/activity of 5F 203 activity in in vitro, in vivo and ex vivo breast ovarian, renal and colon cancer models include cytosolic AhR expression and translocation,11 CYP 1A1 induction,3, 10, 23 CYP2W1 expression,14, 22 DNA adducts' generation7, 14 and DNA strand breaks.7, 8. This evidence concerns the gene CYP2W1 and colonic neoplasm.