GRB2 and schizophrenia: In addition, Sun et al. (2011) found that six of the seven SNPs in the GRB2 gene in the Irish population showed significant association with schizophrenia, and two of them (rs7207618 and rs9912608) remained significant after permutation test or Bonferroni correction test, indicating that GRB2 may be a risk gene for Schizophrenia in the Irish population.