Gene ontology biological process terms such as reverse cholesterol transport, positive regulation of IL‐6 production, response to ethanol, lipoprotein metabolic process, diol metabolic process, xenobiotic metabolic process, and regulation of neuronal synaptic plasticity were overrepresented among MDDgene, implying the important roles of these processes in the pathological processes of MDD. This evidence concerns the gene IL6 and major depressive disorder.