Viral infections are often associated with attenuated host gene transcription and RNase L-mediated cleavage of cellular RNAs (Abernathy and Glaunsinger, 2015), whereas we and others showed that RNA binding protects FUS from irreversible aggregation (Maharana et al., 2018, Shelkovnikova et al., 2014a). Here, FUS is linked to viral infectious disease.