TIA1 and tauopathy: In order to determine how the RNA transcriptome is altered in PS19 tauopathy mice, we isolated total RNA extracts from the cortex of 9-month-old wild-type (WT), PS19 (P301S Tia1+/+) and P301S Tia1+/− mice (refer to the STAR Methods for a detailed description of the breeding scheme).