The importance of our results is further supported by a prior study documenting splicing dysfunction in AD brains (Bai et al., 2013; Barbash et al., 2017), as well as work that specifically examined the function of ELAV proteins (such as HuR) and observed a similarly strong dysfunction of RNA splicing (Scheckel et al., 2016). Here, ELAVL1 is linked to Alzheimer disease.