Many of the genes identified were already identified by NetDecoder as key genes in human AD versus age-matched control brain tissues, including APP, UBC, MYC, PARK2, MDM2, HDACs, TARDBP, RELA, HSP90, FYN, UBE2, and SUMO subunits, among others (Figures 5 and S3) (da Rocha et al., 2016). This evidence concerns the gene APP and Alzheimer disease.