MAPT and tauopathy: We also demonstrated that in pathological murine or human tauopathy, somatodendritic tau co-localizes with TIA1, an RBP with an intrinsically disordered region (IDR, also referred to as a low-complexity or prion-like domain) that functions as a core nucleating SG protein, which stimulates the regulated aggregation of additional RBPs in the cytoplasm (Anderson and Kedersha, 2008; Vanderweyde et al., 2012, 2016).