Many of the RBPs associated with the spliceosome aggregate in AD and mouse models of tauopathy, some co-localizing with tau inclusions, such as TIA1, and others forming independent inclusions, such as TDP-43, U1–70K, and G3BP1 (Amador-Ortiz et al., 2007; Arai et al., 2009; Bai et al., 2013; Bigio et al., 2010; Vanderweyde et al., 2012, 2016). This evidence concerns the gene TIA1 and tauopathy.