APP and neurodegenerative disease: Many of the genes identified in our NetDecoder analysis were also previously identified as being key genes in human neurodegenerative diseases, including APP, PARK2, HTT, TARDBP, G3BP1, UBC, SETX, FYN, RELA, TP53, HDACs, UBE2I, and SUMO, among others (Ahn et al., 2009; Chen et al., 2004; Fernández-Nogales et al., 2014; Klein et al., 2000; Selkoe and Schenk, 2003; Um et al., 2012).