EGF and hepatocellular carcinoma: This EGFR‐ERCC1 interaction was observed to be involved in DDR.9 Second, even without any DNA damage, Andrieux et al. determined that stimulation of wild‐type EGFR by its natural ligand epidermal growth factor (EGF) could increase ERCC1 expression through ERK pathway in hepatocyte and hepatocellular carcinoma cell lines.10