Interestingly, endocan has been shown to enhance the adhesion between monocytes and endothelial cells [24], and Esm1 knock-out mice show decreased vascular permeability and leucocyte extravasation [25], suggesting that endocan expression in endothelial tumour cells could potentially facilitate the trafficking of immune cells to the tumour microenvironment. The gene discussed is ESM1; the disease is neoplasm.