Cushing’s disease (CD), the most frequent cause of endogenous Cushing’s syndrome, is characterized by excess production of adrenocorticotropic hormone (ACTH) by a corticotroph pituitary tumor, leading to hypersecretion of cortisol by the adrenal glands [1–6]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.