In addition, pruriceptive dorsal root ganglion neurons innervating an area of SADBE ACD in mice upregulate CXCR3 and become responsive to CXCL10.35 A CXCR3 antagonist blocked the spontaneous site-directed scratching evoked by CXCL10 but not wiping.35 It was hypothesized that during the development of ACD, a cytokine from the skin such as TNF-α or IL-1β may have been retrogradely transported to the dorsal root ganglion, resulting in an upregulation of chemokine signaling and an increased density of voltage-gated sodium currents. The gene discussed is IL1B; the disease is granular corneal dystrophy type II.